Ripasudil trade name Glanatec , a derivative of fasudil , is a rho kinase inhibitor drug previously known as K [1] used for the treatment of glaucoma and ocular hypertension. The S configuration at the 2-position on the 1,4-diazepane ring of Ripasudil is what gives the drug its characteristic effect. Ripasudil was originally developed from fasudil, as both compounds share the same core structure of 5- 1,4-diazepanylsulfonyl isoquinoline. In short, "ripasudil showed much more potent and selective Rho-kinase inhibitory activity than fasudil". According to a report submitted to the Japanese Pharmaceuticals and Medical Devices Agency regarding Glanatec, ripasudil hydrochloride hydrate showed no binding affinity for receptors of the adrenergic , angiotensin II , endothelin , glutamate , histamine , muscarinic , or prostanoid variety.

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A Nature Research Journal. THE Huntsman limestone stromatolites were originally described by Macgregor 1. Recent work refs 2—5 and T. Hoering personal communication has established their organic origin beyond reasonable doubt, and shown that macro, micro and chemofossils occur together in the Huntsman limestone. Far less attention has been paid to the stratigraphic and absolute age relations of the limestone in which they occur.

As a result of recent detailed field work in and around the quarries, and a comprehensive attack on the ages of granitic events in the southern half of Rhodesia, we can now give a revised estimate of the age of these ancient organisms. Macgregor, A. Google Scholar. Cloud, P. Barghoorn, E. Oberlies, F. Wilson, J. Molyneux, A. Download references. Reprints and Permissions. BOND, G. Age of the Huntsman Limestone Bulawayan Stromatolites. Nature , — Download citation.

Received : 10 May Issue Date : 03 August Geological Society, London, Special Publications FEBS Letters Precambrian Research By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Advanced search. Skip to main content. Subscribe Search My Account Login. Register your interest. Access through your institution. Buy or subscribe.

Change institution. Rent or Buy article Get time limited or full article access on ReadCube. References 1 Macgregor, A. BOND View author publications.

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Further reading Fossil evidence of Archaean life J. Rock , A. Davis , D. Hutchison , M. Smith Geological Society, London, Special Publications Evidence for a novel voltage-activated channel in the outer mitochondrial membrane K.

Kinnally , H. Martin , E. Bickle Precambrian Research Strontium geochemistry and carbon and oxygen isotopic compositions of lower proterozoic dolomite and calcite marbles from the Marmorilik Formation, West Greenland Adam A. Garde Precambrian Research Comments By submitting a comment you agree to abide by our Terms and Community Guidelines.

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Age of the Huntsman Limestone (Bulawayan) Stromatolites


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