Hyperinsulinemia and insulin resistance in children. Oaxaca, Oax. Correspondencia a :. Background: Obesity during childhood is a risk factor for developing cardiovascular diseases during adulthood. Aim : To measure insulin and glucose levels and parameters of insulin resistance in obese, overweight and normal weight Mexican children. Body weight, blood pressure and waist circumference were measured and a blood sample was obtained to measure fasting glucose and insulin levels.
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Hyperinsulinism in infancy and childhood: when an insulin level is not always enough. Andrew A. Palladino; Michael J. Bennett; Charles A. O HI pode estar associado ao estresse perinatal, como asfixia do nascimento, toxemia materna, prematuridade ou retardo do crescimento intra-uterino, resultando em hipoglicemia neonatal prolongada.
Hyperinsulinism HI is the most common cause of both transient and permanent disorders of hypoglycemia. HI is characterized by dysregulated insulin secretion, which results in persistent mild to severe hypoglycemia. The various forms of HI represent a group of clinically, genetically, and morphologically heterogeneous disorders. Hyperinsulinism may be associated with perinatal stress such as birth asphyxia, maternal toxemia, prematurity or intrauterine growth retardation, resulting in prolonged neonatal hypoglycemia.
Mimickers of hyperinsulinism include neonatal panhypopituitarism, drug-induced hypoglycemia, insulinoma, antiinsulin and insulin-receptor stimulating antibodies, Beckwith-Wiedemann Syndrome, and congenital glycosylation disorders. Genetic testing is available at commercial laboratories for genes known to be associated with hyperinsulinism. Acute insulin response AIR tests are useful in phenotypic characterization. Imaging and histological tools are also available to diagnose and classify hyperinsulinism.
SUMMARY: The treatment of hyperinsulinism requires a multidisciplinary approach that includes pediatric endocrinologists, radiologists, surgeons, and pathologists who are trained to diagnose, identify and treat hyperinsulinism. SUR-1 e Kir6. Outras formas de hiperinsulinismo. Pan-hipopituitarismo neonatal. Hipoglicemia induzida por droga. Anticorpos antiinsulina e anti-receptores estimulantes de insulina.
Exames de imagem no HI. Idiopathic spontaneously occurring hypoglycemia in infants: clinical significance of problem and treatment. Mechanisms of disease: advances in diagnosis and treatment of hyperinsulinism in neonates.
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