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Introduction: Perinatal asphyxia remains a major cause of both mortality and neurological morbidity. The only standard therapy is moderate hypothermia, whose efficacy, despite proved, is limited, being partially effective.

Development: The capacity of hypothermia in promoting cell proliferation in the neurogenic niches of the central nervous system remains subject of investigation. The use of therapeutic agents such as erythropoietin and cannabinoids and mesenchymal stem cells have shown promising results in experimental models of perinatal asphyxia, being able of modulate neurogenesis, neuronal plasticity and neuroreparation processes after hypoxic-ischemic brain injury.

Conclusions: The effects of these therapies in clinics are still unknown, so as if the newborn cells will be able to effectively integrate in the existing neuronal networks or if they will develop their proper functions in a brain-damaged microenvironment, thus being necessary new works focused on the evaluation of the real potential of these therapies in the modulation of neurogenesis after neonatal hypoxia-ischemia. La asfixia perinatal continua siendo una de las mayores causas de morbimortalidad neurologica.

La unica aproximacion terapeutica actual consiste en la hipotermia moderada, cuya eficacia, aunque constatada, no siempre consigue una recuperacion funcional total. Se desconoce con certeza si la hipotermia tiene la capacidad de promover la proliferacion celular en los nichos neurogenicos cerebrales, donde permanecen celulas madre neuronales con capacidad de proliferacion y diferenciacion.

Aun se desconocen los efectos de estas terapias en modelos clinicos y si las celulas recien formadas seran capaces de integrarse de forma efectiva en las redes neuronales existentes o si podran desarrollar sus funciones adecuadamente en un microambiente de lesion cerebral, por lo que se hace necesario el desarrollo de nuevos trabajos enfocados a evaluar el potencial real de estos agentes en la modulacion terapeutica de la neurogenesis tras una hipoxia-isquemia neonatal. This site needs JavaScript to work properly.

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Full-text links Cite Favorites. Abstract in English , Spanish. Similar articles Safety and efficacy of topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia NeoNATI.

Filippi L, et al. BMC Pediatr. Clinical Trial. Alonso-Alconada D, et al. Rev Neurol. PMID: Review. The endogenous regenerative capacity of the damaged newborn brain: boosting neurogenesis with mesenchymal stem cell treatment. Donega V, et al. J Cereb Blood Flow Metab. Epub Feb Interaction between hypothermia and delayed mesenchymal stem cell therapy in neonatal hypoxic-ischemic brain injury.

Herz J, et al. Brain Behav Immun. PMID: Intervention strategies for neonatal hypoxic-ischemic cerebral injury. Perlman JM. Clin Ther. Show more similar articles See all similar articles. Publication types Review Actions. MeSH terms Humans Actions. Infant, Newborn Actions. Full-text links [x] Viguera Editores, S. Copy Download.








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