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Heterochromatin decondesation in Creole cattle carrier of Robertsonian franslocation rob 1; Action of 5-azacytidine-C. Facultad de Veterinaria. Lasplaces Fax: Montevideo, Uruguay. Autor para correspondencia: aliposvet gmail. The Robertsonian translocation rob1; 29 is widely spread in commercial breeds and specially in genetic reserve of American Creole cattle.
It is also described a delay on embryo development in front of normal ones. The action of 5-aza-C, as an hypomethylated agent, could permitted to decondensate the constitutive or facultative heterochromatin. In this work we made induction with the 5-aza-C 10mM, 2 hrs analogs, in lymphocyte cultures of female and male carriers and normal Creole cattle. The DNA hypometilation is found in the inactive X chromosome of late replication as it is incorporated during the last hours of cell culture.
The decondensing effects of 5-aza-C analogs is observed in multiple regions of the autosomes chromatin, the rob1; 29 and the BTA1. A correlation between hypometilated regions and decondensed of facultative conditional heterochromatin is related with genomic instability, and epigenetic reprogramming.
Di Meo y col. Tellechea y col. El colcemid 0. Se observaron regiones condensadas que no fueron alteradas por el inductor. Arruga, M. Artigas, R. Danielak-Czech, B ; Slota, E.. Mutagen-induced chromosome instability in farm animals. J Anim Feed Sci De Luca, JC. Theriogenology 15; 58 7 : Di Berardino, D. Localization of BrdU-induced break sites in bovine chromosomes. Caryologia 36 3 Cytogenet Cell Genet Di Meo, A. Chromosome Res Gustavsson, I. Cytogenetics, distribution and phenotypic effects of a translocation in Swedish cattle.
Hereditas Haaf, T. The effects of 5-azacytidine and 5-azadeoxicytidine on chromosome structure and function: implications for methylation- associated cellular process. Thr Experimental condensation inhibition in constitutive heterochromatin of mammalian chromosomes. Cell Genet Holmquist, G. Chromosome organization and chromatin modification: influence on genome function and evolution.
Joerg, H. J Anim Breed Genet Kastelic, JK. Causas no infecciosas de muerte embrionaria en ganado bovino. King, WA. Embryo-mediated pregnancy failure in cattle. Can Vet J Pintado, E.
Rev Neurol , Postiglioni, A. Cytogenetic Characterization of a sample of Uruguayan Creole cattle. Arch Zootec Rangel-Figueiredo, T. Frequency and distribution of rob 1; 29 in three Portuguese cattle breeds. Rev Col Cienc Pec Schifferli, C. Shibler, L. Genome Res Sumner, A. A simple technique for demonstrating centromeric heterochromatin. Tellechea, B. Avances en el estudio de la heterocromatina en rob1; Wurster, DH. Services on Demand Article.
Spanish pdf Article in xml format Article references How to cite this article Automatic translation Send this article by e-mail. All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Cra 32 no. How to cite this article.
El correcto empaquetamiento del genoma es esencial para mantener su estabilidad
Enzimas modificadoras de histonas
Empaquetamiento de la cromatina