ACTEMRA PACKAGE INSERT PDF

Patients treated with ACTEMRA are at increased risk for developing serious infections that may lead to hospitalization or death, including tuberculosis TB , bacterial, invasive fungal, viral, or other opportunistic infections. The risks and benefits of treatment with ACTEMRA should be carefully considered prior to initiating therapy in patients with chronic or recurrent infection. Patients should be closely monitored for the development of signs and symptoms of infection during and after treatment with ACTEMRA, including the possible development of tuberculosis in patients who tested negative for latent tuberculosis infection prior to initiating therapy. Events of gastrointestinal GI perforation have been reported in clinical trials, primarily as complications of diverticulitis in RA patients. Promptly evaluate patients presenting with new-onset abdominal symptoms for early identification of GI perforation. Some of these cases have resulted in liver transplant or death.

Author:Arashakar Fauk
Country:Malawi
Language:English (Spanish)
Genre:Love
Published (Last):13 July 2006
Pages:208
PDF File Size:1.86 Mb
ePub File Size:14.87 Mb
ISBN:130-5-56621-429-2
Downloads:81789
Price:Free* [*Free Regsitration Required]
Uploader:Doutilar



This can make you more likely to get infections or make any current infection worse. Some people have serious infections while taking ACTEMRA, including tuberculosis TB , and infections caused by bacteria, fungi, or viruses that can spread throughout the body. Some people have died from these infections. Be sure to talk to your healthcare provider if you see any signs of these serious side effects:. This happens most often in people who also take nonsteroidal anti-inflammatory drugs NSAIDs , corticosteroids, or methotrexate.

Tell your healthcare provider right away if you see any of these side effects: fever, stomach-area pain that does not go away, or if you see a change in your bowel habits. Some people have experienced serious life-threatening liver problems, which required liver transplant or led to death. Tell your healthcare provider right away if you have any of the following symptoms:. If you have polyarticular juvenile idiopathic arthritis PJIA you will have blood tests done every 4 to 8 weeks during treatment.

If you have systemic juvenile idiopathic arthritis SJIA you will have blood tests done every 2 to 4 weeks during treatment. Your healthcare provider will determine how often you will have follow-up blood tests. Make sure you get all your follow-up blood tests done as ordered by your healthcare provider.

Tell your healthcare provider if you have any signs of these symptoms:. These reactions can happen with any infusion or injection of ACTEMRA, even if they did not occur with an earlier infusion or injection. Tell your healthcare provider before your next dose if you had hives, rash or flushing after your injection. Contact immediately, as well as your healthcare provider, if you experience any of these reactions:.

Tell your healthcare provider if you are planning to become pregnant, are pregnant, plan to breast-feed, or are breast-feeding. You should not do both. The purpose of this registry is to check the health of the pregnant mother and her baby. To learn more, call or talk to your healthcare provider to register. Tell your healthcare provider if you have any side effects. You may also report side effects to Genentech at The link you have selected will take you away from this site to one that is not owned or controlled by Genentech, Inc.

Genentech, Inc. Genentech does not recommend and does not endorse the content on any third-party websites. Your use of third-party websites is at your own risk and subject to the terms and conditions of use for such sites. The information contained in this section of the site is intended for U. Click "OK" if you are a healthcare professional. Before starting ACTEMRA, tell your healthcare provider if you have: an infection, think you may have an infection, are being treated for an infection, or get a lot of infections that return.

Symptoms of an infection, with or without a fever, include sweating or chills; shortness of breath; warm, red or painful skin or sores on your body; feeling very tired; muscle aches; blood in phlegm; diarrhea or stomach pain; cough; weight loss; burning when you urinate or urinating more than normal any of the following conditions that may give you a higher chance of getting infections: diabetes, HIV, or a weak immune system tuberculosis TB , or have been in close contact with someone with TB live or have lived, or have traveled to certain parts of the United States where there is an increased chance of getting fungal infections.

Liver problems Hepatotoxicity Some people have experienced serious life-threatening liver problems, which required liver transplant or led to death. These blood tests are to check for the following side effects of ACTEMRA: Low neutrophil count: neutrophils are white blood cells that help the body fight infection Low platelet count: platelets are blood cells that help with clotting, which stops bleeding Increase in liver function test levels Increase in blood cholesterol levels: your cholesterol levels should be checked 4 to 8 weeks after you start receiving ACTEMRA.

The most common side effects of ACTEMRA include: upper respiratory tract infections common cold, sinus infections headache increased blood pressure hypertension injection site reactions. Moderate to Severe Rheumatoid Arthritis. Giant Cell Arteritis. Tell your healthcare provider if you have any signs of these symptoms: feel very tired skin or eyes look yellow little or no appetite vomiting clay-colored bowel movements fevers chills stomach discomfort muscle aches dark urine skin rash.

Cancel OK. Your email has been sent! Thanks for sharing this page.

74LS76 PDF

Actemra FAQ

This can make you more likely to get infections or make any current infection worse. Some people have serious infections while taking ACTEMRA, including tuberculosis TB , and infections caused by bacteria, fungi, or viruses that can spread throughout the body. Some people have died from these infections. Be sure to talk to your healthcare provider if you see any signs of these serious side effects:.

FUNCIONES DE LA DIGEMID PDF

Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids. The risks and benefits of treatment with ACTEMRA should be carefully considered prior to initiating therapy in patients with chronic or recurrent infection. Patients should be closely monitored for the development of signs and symptoms of infection during and after treatment with ACTEMRA, including the possible development of tuberculosis in patients who tested negative for latent tuberculosis infection prior to initiating therapy [see Warnings and Precautions 5. The recommended dosage of ACTEMRA for adult patients given as a minute single intravenous drip infusion is 4 mg per kg every 4 weeks followed by an increase to 8 mg per kg every 4 weeks based on clinical response. When transitioning from ACTEMRA intravenous therapy to subcutaneous administration administer the first subcutaneous dose instead of the next scheduled intravenous dose.

LA NUEVA BABILONIA CONSTANT PDF

What is Actemra? How does Actemra work? Who makes Actemra? What is the recommended dosing of Actemra? Where can I view the Actemra package insert?

AMEN BY SISTER JESME PDF

.

Related Articles